The San Francisco 49ers are at risk of being without another star offensive player for Week 3.

Tight end George Kittle is experiencing hamstring tightness and did not practice Thursday, according to Adam Schefter of ESPN. That practice absence makes his availability for Sunday’s game against the division-rival Los Angeles Rams an unknown.

The 49ers are already without several key players heading into this road matchup. All-Pro RB Christian McCaffrey is on injured reserve with a leg issue and WR Deebo Samuel will not play, either. If Kittle cannot go, that would leave San Francisco without three of its top weapons on offense and would likely put a heavy onus on Brandon Aiyuk, who is still getting up to speed after his preseason holdout.

The 49ers are coming off a surprising loss to the Minnesota Vikings, but are still 1-1 on the season. The good news from their standpoint, at least for this weekend, is that the Rams are about as banged up as they are.





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